Journal
NEUROGASTROENTEROLOGY AND MOTILITY
Volume 24, Issue 10, Pages 895-913Publisher
WILEY
DOI: 10.1111/j.1365-2982.2012.01993.x
Keywords
chronic fatigue syndrome; fibromyalgia; functional dyspepsia; interstitial cystitis; painful bladder syndrome; irritable bowel syndrome; temporomandibular joint disorder
Funding
- National Institutes of Health [R01 AR46122, P50 DK64539]
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Background Irritable bowel syndrome and other gastrointestinal (GI) and non-GI disorders such as functional dyspepsia, fibromyalgia, temporomandibular joint disorder, interstitial cystitis/painful bladder syndrome, and chronic fatigue syndrome are known as functional pain syndromes. They commonly coexist within the same individual. The pathophysiologic mechanisms of these disorders are not well understood, but it has been hypothesized that they share a common pathogenesis. Purpose The objective of this review is to discuss the proposed pathophysiologic mechanisms, which have been similarly studied in these conditions. These mechanisms include enhanced pain perception, altered regional brain activation, infectious etiologies, dysregulations in immune and neuroendocrine function, and genetic susceptibility. Studies suggest that these functional disorders are multifactorial, but factors which increase the vulnerability of developing these conditions are shared.
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