Journal
NEUROGASTROENTEROLOGY AND MOTILITY
Volume 24, Issue 11, Pages e557-e560Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2982.2012.01999.x
Keywords
2; 4; 6-trinitrobenzenesulfonic acid-induced colitis; animal models of gastrointestinal inflammation; colorectal pain; inflammatory bowel disease; RN 1734; Transient Receptor Potential Vanilloid 4
Funding
- University of Calgary Research Grant committee
- Deutsche Forschungsgemeinschaft [STO 645/6-1]
- Iuventus Plus program of the Polish Ministry of Science and Higher Education [0119/IP1/2011/71]
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Recent reports suggested that the activation of Transient Receptor Potential Vanilloid 4 (TRPV4) receptors in the gastrointestinal tract has pro-inflammatory effects. In this study, we demonstrated for the first time that TRPV4 mRNA expression is up-regulated in patients with inflammatory bowel diseases (IBD). Furthermore, selective blockade of TRPV4 in the 2,4,6-trinitrobenzenesulfonic acid animal model alleviates colitis and pain associated with the intestinal inflammation. Our study indicates that TRPV4 may play a role in mechanisms of defense in intestinal inflammation and that TRPV4 may be an attractive target for future systemic or topic anti-inflammatory treatment in patients with IBD.
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