Journal
NEUROEPIDEMIOLOGY
Volume 36, Issue 4, Pages 223-229Publisher
KARGER
DOI: 10.1159/000327748
Keywords
Parkinson disease; Risk factors; Oxidative stress; Epidemiology; Uric acid
Funding
- University of Pittsburgh Claude D. Pepper Older Americans Independence Center [P30 AG-024827]
- NHLBI [N01 HC-35129, N01 HC-45133, N01 HC-75150, N01 HC-85079, N01 HC-85086, N01 HC-15103, N01 HC-55222, U01 HL-080295, R01 HL-075366, HL007902]
- NINDS
- NIA [R01 AG-023629, R01 AG-15928, R01 AG-20098, R01 AG-027058]
- University of Pittsburgh [1 KL2 RR024154-01]
- DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS [N01HC055222, N01HC085086, N01HC015103, N01HC035129, N01HC075150, N01HC045133, N01HC085079] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000005] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [KL2RR024154] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL007902, U01HL080295, R01HL075366] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG027058, R01AG015928, P30AG024827, R01AG020098, R01AG023629] Funding Source: NIH RePORTER
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Background/Aims: Studies suggest an inverse association between urate concentration and the risk of Parkinson disease (PD). We investigated this in the Cardiovascular Health Study in an elderly community-based cohort of adults. Methods: The association of baseline urate (mu mol/l) and incident PD over 14 years was assessed with locally weighted scatterplot smoothing (LOESS) regression from which categories of low (<300 mu mol/l), middle (300-500 mu mol/l), and high (>500 mu mol/l) urate ranges were derived. Multivariate logistic regression models assessed the risk of PD for each urate range. Linear and quadratic terms were tested when modeling the association between urate and the risk of PD. Results: Women had significantly lower urate concentrations than did men [316.8 mu mol/l (SD 88.0) vs. 367.4 mu mol/l (SD 87.7), p < 0.0001] and in women no associations between urate and PD risk were observed. In men, LOESS curves suggested a U-shaped or threshold effect between urate and PD risk. With the middle range as reference, the risk of developing PD was significantly increased for urate <300 mu mol/l (OR 1.69, 95% Cl 1.03-2.78) but not for urate >500 mu mol/l (OR 1.55, 95% Cl 0.72-3.32) in men. A negative linear term was significant for urate <500 mu mol/l, and across the entire range a convex quadratic term was significant. Conclusions: Results suggest a more complex relationship than previously reported between urate levels and the risk of PD in men. Low urate concentrations were associated with a higher PD risk and high urate concentrations were not associated with a further decrease in PD risk. Copyright (C) 2011 S. Karger AG, Basel
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