Journal
NEUROEPIDEMIOLOGY
Volume 35, Issue 3, Pages 191-195Publisher
KARGER
DOI: 10.1159/000315157
Keywords
alpha-Synuclein; Pesticides; Parkinson's disease; Smoking; Age of onset; Paraquat; Interaction; REP1
Funding
- NIEHS [T32ES01545, ES10544, U54ES12078, 5P30ES07048]
- NINDS [NS038367]
- DOD [PC051037]
- Michael J. Fox Foundation
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES007048, R01ES010544, U54ES012078] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P50NS038367] Funding Source: NIH RePORTER
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Background: Although of great interest and suggested in prior reports, possible alpha-synuclein (SNCA) gene-environment interactions have not been well investigated in humans. Methods: We used a population-based approach to examine whether the risk of Parkinson's disease (PD) depended on the combined presence of SNCA variations and two important environmental factors, pesticide exposures and smoking. Results/Conclusions: Similar to recent meta-and pooled analyses, our data suggest a lower PD risk in subjects who were either homozygous or heterozygous for the SNCA REP1 259 genotype, and a higher risk in subjects who were either homozygous or heterozygous for the REP1 263 genotype, especially among subjects with an age of onset <= 68 years. More importantly, while analyses of interactions were limited by small cell sizes, risk due to SNCA variations seemed to vary with pesticide exposure and smoking, especially in younger onset cases, suggesting an age-of-onset effect. Copyright (C) 2010 S. Karger AG, Basel
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