Journal
NEUROEPIDEMIOLOGY
Volume 30, Issue 1, Pages 58-69Publisher
KARGER
DOI: 10.1159/000115751
Keywords
cognitive impairment; prevalence; incidence; risk factors; cohort studies; data collection instruments
Funding
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR030582] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [K01MH068351] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [K01AG028573, U01AG006786, P50AG016574] Funding Source: NIH RePORTER
- NIAMS NIH HHS [R01 AR30582, R01 AR030582] Funding Source: Medline
- NIA NIH HHS [P50 AG016574, K01 AG028573, U01 AG06786, P50 AG16574, U01 AG006786] Funding Source: Medline
- NIMH NIH HHS [K01 MH068351, K01 MH68351] Funding Source: Medline
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Background: The objective of this study was to establish a prospective population-based cohort to investigate the prevalence, incidence and risk factors for mild cognitive impairment (MCI) and dementia. Methods: The Olmsted County, Minn., population, aged 70-89 years on October 1, 2004, was enumerated using the Rochester Epidemiology Project. Eligible subjects were randomly selected and invited to participate. Participants underwent a comprehensive in-person evaluation including the Clinical Dementia Rating Scale, a neurological evaluation and neuropsychological testing. A consensus diagnosis of normal cognition, MCI or dementia was made by a panel using previously published criteria. A subsample of subjects was studied via telephone interview. Results: Four hundred and two subjects with dementia were identified from a detailed review of their medical records but were not contacted. At baseline, we successfully evaluated 703 women aged 70 - 79 years, 769 women aged 80-89 years, 730 men aged 70-79 years and 517 men aged 80-89 years (total n = 2,719). Among the participants, 2,050 subjects were evaluated in person and 669 via telephone. Conclusions: Strengths of the study are that the subjects were randomly selected from a defined population, the majority of the subjects were examined in person, and MCI was defined using published criteria. Here, we report the design and sampling, participation, baseline measures and sample characteristics. Copyright (c) 2008 S. Karger AG, Basel.
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