Journal
NEUROENDOCRINOLOGY
Volume 97, Issue 4, Pages 363-368Publisher
KARGER
DOI: 10.1159/000351077
Keywords
STX; Estradiol; Lordosis; Arcuate nucleus; Estrogen receptor
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Funding
- [DA013185]
- [T32 HD07228]
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Membrane initiated estradiol signaling has been shown to be vital for multiple physiological processes. Several receptors have been proposed to mediate the actions of estradiol at the membrane. Here, we examined the ability of STX, an agonist of a novel putative membrane estrogen receptor, to activate sexually receptive behavior in the female rat. Infusions of STX into the arcuate nucleus of the hypothalamus resulted in the activation and internalization of mu-opioid receptors in the medial preoptic nucleus, an action that is required for lordosis behavior. Indeed, STX was able to augment sexual receptivity in female rats given a sub-behavioral dose of estradiol. However, if the mGluR1a antagonist, LY367,385, was administered prior to STX, its circuit-activating effects, the internalization of mu-opioid receptors, were lost. This suggests that the receptor stimulated by STX activates rapid membrane-initiated signaling through an interaction with mGluR1a - an effect previously described for estrogen receptor-a at the membrane. Copyright (C) 2013 S. Karger AG, Basel
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