Journal
NEUROENDOCRINOLOGY
Volume 96, Issue 2, Pages 111-118Publisher
KARGER
DOI: 10.1159/000338397
Keywords
Estradiol; Hypothalamus; Pituitary; Behavior; Anxiety
Categories
Funding
- National Institutes of Health [R01-NS039951, R01 HD062512, R01 MH82900]
- National Science Foundation [IOS-0937331]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R01HD062512] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH082900] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS039951] Funding Source: NIH RePORTER
- Direct For Biological Sciences [0937331] Funding Source: National Science Foundation
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It is now well established that estrogens can influence a panoply of physiological and behavioral functions. In many instances, the effects of estrogens are mediated by the 'classical' actions of two different estrogen receptors (ERs), ER alpha or ER beta. ER alpha and ER beta appear to have opposing actions in the control of stress responses and modulate different neurotransmitter or neuropeptide systems. Studies elucidating the molecular mechanisms for such regulatory processes are currently in progress. Furthermore, the use of ER alpha and ER beta knockout mouse lines has allowed the exploration of the importance of these receptors in behavioral responses such as anxiety-like and depressive-like behaviors. This review examines some of the recent advances in our knowledge of hormonal control of neuroendocrine and behavioral responses to stress and underscore the importance of these receptors as future therapeutic targets for control of stress-related signaling pathways. Copyright (C) 2012 S. Karger AG, Basel
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