Journal
NEUROENDOCRINOLOGY
Volume 89, Issue 2, Pages 223-230Publisher
KARGER
DOI: 10.1159/000167796
Keywords
Somatostatin receptor; Well-differentiated tumours; Somatostatin analogues; Survival rate
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Funding
- Italian Ministry of Universities and the Italian Ministry of Health
- Associazione Italiana Ricerca Cancro
- Fondazione Giorgio Zanotto and Fondazione Cariverona
- European Union FP6 program MolDiagPaca, IPSEN Italia SpA
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The majority of gastroenteropancreatic well-differentiated endocrine carcinomas (WDEC) express somatostatin receptors ( SSTR). To correlate the expression of SSTR subtypes by reverse transcriptase-polymerase chain reaction (RT-PCR) with clinicopathological features and survival in a group of WDEC patients, 42 WDEC tissue specimens from 33 patients were analysed. All patients were treated with somatostatin analogues and had a median follow-up period of 45 months ( range 6-196). Neither SSTR2 and SSTR5 expression nor Ki-67 level alone correlated with survival. A significantly better survival rate was observed in patients with tumours expressing SSTR2, SSTR5 and Ki-67 !2%, compared to those with SSTR2- and SSTR5-negative tumours and Ki-67 >= 2% (p<0.038), with 5-year survival rates of 91 vs. 43%, respectively. Expression of SSTR2 and SSTR5 appears to play a positive prognostic role, possibly correlated with the high affinity that the available somatostatin analogues display for these 2 specific SSTR subtypes. Copyright (c) 2008 S. Karger AG, Basel
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