Related references
Note: Only part of the references are listed.Possible roles of amyloid intracellular domain of amyloid precursor protein
Keun-A Chang et al.
BMB Reports (2011)
Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease
Gen He et al.
NATURE (2010)
p53 Is Regulated by and Regulates Members of the gamma-Secretase Complex
Frederic Checler et al.
NEURODEGENERATIVE DISEASES (2010)
beta-Amyloid precursor protein metabolism: focus on the functions and degradation of its intracellular domain
Erica Buoso et al.
PHARMACOLOGICAL RESEARCH (2010)
Pharmacological evidences for DFK167-sensitive presenilin-independent γ-secretase-like activity
J. Sevalle et al.
JOURNAL OF NEUROCHEMISTRY (2009)
p53-Dependent Transcriptional Control of Cellular Prion by Presenilins
Bruno Vincent et al.
JOURNAL OF NEUROSCIENCE (2009)
In vitro reconstitution of γ-secretase activity using yeast microsomes
Sosuke Yagishita et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics -: Relevance for Alzheimer's disease
Thorsten Mueller et al.
PROGRESS IN NEUROBIOLOGY (2008)
Amyloid precursor protein regulates brain apolipoprotein e and cholesterol metabolism through lipoprotein receptor LRP1
Qiang Liu et al.
NEURON (2007)
Presenilin/γ-secretase-dependent processing of β-amyloid precursor protein regulates EGF receptor expression
Yun-wu Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
p53-dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the γ-secretase complex but is independent of its activity
Julie Dunys et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Presenilin-dependent γ-secretase-mediated control of p53-associated cell death in Alzheimer's disease
CA da Costa et al.
JOURNAL OF NEUROSCIENCE (2006)
TMP21 is a presenilin complex component that modulates γ-secretase but not ε-secretase activity
FS Chen et al.
NATURE (2006)
Catabolism of endogenous and overexpressed APH1a and PEN2: evidence for artifactual involvement of the proteasome in the degradation of overexpressed proteins
J Dunys et al.
BIOCHEMICAL JOURNAL (2006)
A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage
MT Lai et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain
KA Ryan et al.
JOURNAL OF CELL BIOLOGY (2005)
Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors - Selectivity of PS2 in platelet-derived growth factor signaling
DE Kang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
p53 in neuronal apoptosis
C Culmsee et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Presenilin-dependent transcriptional control of the Aβ-degrading enzyme neprilysin by intracellular domains of βAPP and APLP
R Pardossi-Piquard et al.
NEURON (2005)
Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin
A Bergman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation
AS Crystal et al.
BIOCHEMISTRY (2004)
The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor
RC von Rotz et al.
JOURNAL OF CELL SCIENCE (2004)
The role of presenilin cofactors in the γ-secretase complex
N Takasugi et al.
NATURE (2003)
Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular A beta production
CA Wilson et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2003)
Amyloid precursor protein, presenilins, and α-synuclein:: Molecular pathogenesis and pharmacological applications in Alzheimer's disease
YH Suh et al.
PHARMACOLOGICAL REVIEWS (2002)
Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-κB and β-amyloid precursor protein
SH Baek et al.
CELL (2002)
Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons
CA da Costa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Endogenous β-amyloid production in presenilin-deficient embryonic mouse fibroblasts
M Armogida et al.
NATURE CELL BIOLOGY (2001)
The β-secretase, BACE -: A prime drug target for Alzheimer's disease
R Vassar
JOURNAL OF MOLECULAR NEUROSCIENCE (2001)
Regulation of transcription of the human presenilin-1 gene by Ets transcription factors and the p53 protooncogene
M Pastorcic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Neuronal life and death: an essential role for the p53 family
FD Miller et al.
CELL DEATH AND DIFFERENTIATION (2000)