Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 123, Issue -, Pages 13-21Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2018.08.015
Keywords
Kinetic parameters; Neuronal cultures; CFT; Cholesterol; Striatum; Nucleus accumbens
Categories
Funding
- National Institutes of Health [DA031991, DA13147, P20GM104360, P30-GM103329, P20-GM12345]
Ask authors/readers for more resources
The dopamine transporter (DAT) plays a critical role in dopamine (DA) homeostasis by clearing transmitter from the extraneuronal space after vesicular release. DAT serves as a site of action for a variety of addictive and therapeutic reuptake inhibitors, and transport dysfunction is associated with transmitter imbalances in disorders such as schizophrenia, attention deficit hyperactive disorder, bipolar disorder, and Parkinson disease. In this review, we describe some of the model systems that have been used for in vitro analyses of DAT structure, function and regulation, and discuss a potential relationship between transporter kinetic values and membrane cholesterol.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available