4.5 Review

Drosophila melanogaster as a genetic model system to study neurotransmitter transporters

Journal

NEUROCHEMISTRY INTERNATIONAL
Volume 73, Issue -, Pages 71-88

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2014.03.015

Keywords

Drosophila; Neurotransmitter transporter; Vesicular transporter; VMAT; VGAT; VGLUT; VAChT; EAAT; DAT; SERT; GAT; Inebriated; SLC6; SLC1; SLC18; SLC17; Dopamine; Serotonin; GABA; Octopamine; Glutamate; Portabella; Acetylcholine; ChT1; VNUT

Funding

  1. National Institute of Mental Health [R01 MH076900]
  2. National Institute of Environmental Health (NIEHS) [R01 ES015747]
  3. The Brain and Behavior Research Foundation
  4. Joanne and George Miller and Family Endowed Chair in Depression Research at the UCLA Brain Research Institute
  5. NIEHS Center Grant [P01 ES016732]
  6. NIEHS UCLA training grant in Molecular Toxicology
  7. Parkinson's Disease Foundation [PDF-SFW-1336]

Ask authors/readers for more resources

The model genetic organism Drosophila melanogaster, commonly known as the fruit fly, uses many of the same neurotransmitters as mammals and very similar mechanisms of neurotransmitter storage, release and recycling. This system offers a variety of powerful molecular-genetic methods for the study of transporters, many of which would be difficult in mammalian models. We review here progress made using Drosophila to understand the function and regulation of neurotransmitter transporters and discuss future directions for its use. (C) 2014 Elsevier Ltd. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available