Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 71, Issue -, Pages 1-7Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2014.03.005
Keywords
Glioblastoma; Cancer stem cells; Yeast antibody display; Phage antibody display; Biomarkers
Categories
Funding
- Saudi National Guard Health Affairs fellowship [T32GM008692]
- NIH [T32GM007507, UL1RR025011, RC4AA020476]
- NCI [HHSN261201000130C, P30CA014520]
- Center for Stem Cell and Regenerative Medicine, from the University of Wisconsin (Graduate School and Dept. of Neurological Surgery)
- HEADRUSH Brain Tumor Research and Roger Loff Memorial Fund for GBM Research
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Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in humans. It accounts for fifty-two percent of primary brain malignancies in the United States and twenty percent of all primary intracranial tumors. Despite the current standard therapies of maximal safe surgical resection followed by temozolomide and radiotherapy, the median patient survival is still less than 2 years due to inevitable tumor recurrence. Glioblastoma cancer stem cells (GSCs) are a subgroup of tumor cells that are radiation and chemotherapy resistant and likely contribute to rapid tumor recurrence. In order to gain a better understanding of the many GBM-associated mutations, analysis of the GBM cancer genome is ongoing; however, innovative strategies to target GSCs and overcome tumor resistance are needed to improve patient survival. Cancer stem cell biology studies reveal basic understandings of GSC resistance patterns and therapeutic responses. Membrane proteomics using phage and yeast display libraries provides a method to identify novel antibodies and surface antigens to better recognize, isolate, and target GSCs. Altogether, basic GBM and GSC genetics and proteomics studies combined with strategies to discover GSC-targeting agents could lead to novel treatments that significantly improve patient survival and quality of life. (C) 2014 Elsevier Ltd. All rights reserved.
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