Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 63, Issue 5, Pages 458-464Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2013.08.004
Keywords
Glycogen; Glycogen phosphorylase; Potassium; Astrocytes; Na+/K+ ATPase
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Funding
- NIH [1UL1RR033183, KL2 RR033182]
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Recent advances in brain energy metabolism support the notion that glycogen in astrocytes is necessary for the clearance of neuronally-released K+ from the extracellular space. However, how the multiple metabolic pathways involved in K+-induced increase in glycogen turnover are regulated is only partly understood. Here we summarize the current knowledge about the mechanisms that control glycogen metabolism during enhanced K+ uptake. We also describe the action of the ubiquitous Na+/K+ ATPase for both ion transport and intracellular signaling cascades, and emphasize its importance in understanding the complex relation between glycogenolysis and K+ uptake. (C) 2013 Elsevier Ltd. All rights reserved.
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