Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 60, Issue 5, Pages 484-487Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2012.01.027
Keywords
Amyloid precursor protein; Thyroid hormone; Hypothyroidism; TR knockout; Brain
Categories
Funding
- Spanish Ministerio de Ciencia e Innovacion [SAF2009-11150]
Ask authors/readers for more resources
We have previously shown that the thyroid hormone triiodothyronine negatively regulates the transcriptional activity of the p-amyloid precursor protein gene (APP) in cultured murine neuroblastoma cells, by a mechanism that involves binding of the nuclear thyroid hormone receptor (TR) to DNA sequences located within the first exon of the gene. In this report we present results showing that the thyroid hormones also repress the expression of APP in human neuroblastoma cells and in primary cultures of rat neurons. In addition, and in agreement with the results obtained in cultured cells, APP messenger RNA and protein levels are significantly higher in the brain of hypothyroid rats and mice, and also in Alzheimer-related brain regions dissected from KO mice lacking TRs. These results show that binding of the thyroid hormones to their nuclear receptors mediate their repressive effect on APP gene expression in vivo. (C) 2012 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available