Journal
NEUROCHEMICAL RESEARCH
Volume 39, Issue 9, Pages 1753-1758Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-014-1370-7
Keywords
Atractylenolide III; Atractylodes macrocephala; Excitotoxicity; Apoptosis; Caspase
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Funding
- National Natural Science Foundation of China [30472073]
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Glutamate-induced excitotoxicity appears to play a crucial role in neurological disorders. Neuroprotection against glutamate-induced excitotoxicity has been proposed as a therapeutic strategy for preventing and/or treating these excitotoxicity-mediated diseases. In the present study, atractylenolide III, which exhibited significantly neuroprotective effect against glutamate-induced neuronal apoptosis, was isolated from Atractylodes macrocephala by means of bioactivity-guided fractionation. The inhibitory effect of atractylenolide III on glutamate-induced neuronal apoptosis was in a concentration-dependent manner. The anti-apoptotic property of atractylenolide III might be mediated, in part, via inhibiting caspase signaling pathway. Atractylenolide III may have therapeutic potential in excitotoxicity-mediated neurological diseases.
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