Journal
NEUROCHEMICAL RESEARCH
Volume 40, Issue 1, Pages 165-171Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-014-1480-2
Keywords
Microglia; Biochanin A; NF-kappa B; PGE2; PPAR-gamma; LPS
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Biochanin A, one of the major isoflavonoids in red clover or cabbage, has been reported to have anti-inflammatory effects. However, the molecular mechanism underlying the anti-inflammatory effects of biochanin A has not been completely elucidated. The aim of this study was to investigate the anti-inflammatory effect and mechanism on lipopolysaccharide (LPS)-stimulated BV2 microglia. The results showed that biochanin A suppressed LPS-induced inflammatory mediators nitric oxide, prostaglandin E-2 and inflammatory cytokines TNF-alpha and IL-1 beta production. LPS-induced NF-kappa B activation was also inhibited by biochanin A. In addition, biochanin A up-regulated the expression of PPAR-gamma and the anti-inflammatory effects of biochanin A can be abolished by PPAR-gamma antagonist GW9662. These results suggest that biochanin A exerts an anti-inflammatory property by activating PPAR-gamma, thereby attenuating NF-kappa B activation and the release of pro-inflammatory mediators.
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