Journal
NEUROCHEMICAL RESEARCH
Volume 34, Issue 12, Pages 2122-2132Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-009-9997-5
Keywords
Free radicals; Oxidative stress; Aging; Alzheimer's disease; Vascular dementia; Parkinson disease; Type II diabetes mellitus
Categories
Funding
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
- Fundacion Argentina Contra las Enfermedades Neurologicas del Envejecimiento (FACENE) of Argentina
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Markers of oxidative stress were measured in blood samples of 338 subjects (965 observations): Alzheimer's, vascular dementia, diabetes (type II) superimposed to dementias, Parkinson's disease and controls. Patients showed increased thiobarbituric acid reactive substances (+21%; P < 0.05), copper-zinc superoxide dismutase (+64%; P < 0.001) and decreased antioxidant capacity (-28%; P < 0.001); pairs of variables resulted linearly related across groups (P < 0.001). Catalase and glutathione peroxidase, involved in discrimination between diseases, resulted non-significant. When diabetes is superimposed with dementias, changes resulted less marked but significant. Also, superoxide dismutase resulted not linearly correlated with any other variable or age-related (pure Alzheimer's peaks at 70 years, P < 0.001). Systemic oxidative stress was significantly associated (P a parts per thousand(a) 0.001) with all diseases indicating a disbalance in peripheral/adaptive responses to oxidative disorders through different free radical metabolic pathways. While other changes-methionine cycle, insulin correlation-are also associated with dementias, the responses presented here show a simple linear relation between prooxidants and antioxidant defenses.
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