Journal
NEUROCHEMICAL RESEARCH
Volume 33, Issue 12, Pages 2427-2435Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-008-9681-1
Keywords
Astrocytes; Cell migration; Cytokines; Cytoskeleton; cGMP; Guanylyl cyclase; Lipopolysaccharide; Microglia; Natriuretic peptides; Neuroinflammation; Nitric oxide synthase; Phagocytosis; Reactive gliosis; Rho GTPases
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Funding
- Ministerio de Educacion y Ciencia (MEC), Spain [SAF2004-01717]
- Direccio General de Recerca (DGR) [SGR2005-939]
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A large body of evidence supports a role for the NO-cGMP-protein kinase G pathway in the regulation of synaptic transmission and plasticity, brain development and neuroprotection. Circumstancial evidence implicates natriuretic peptide-stimulated cGMP formation in the same CNS functions. In addition to neurons, both cGMP-mediated pathways are functional in glial cells and an increasing number of reports indicate that they may control important aspects of glial cell physiology relevant to neuronal function. In this article we briefly review the regulation of cGMP formation in glial cells and summarize recent evidence indicating that cGMP-mediated pathways can play important roles in astroglial and microglial function in normal and diseased brain.
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