Journal
NEUROCHEMICAL RESEARCH
Volume 33, Issue 9, Pages 1783-1788Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-008-9629-5
Keywords
nicotine; Alzheimer; transgenic; APP; A beta-42
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Nicotine is the principal psychoactive ingredient in cigarette smoke, and has been associated with health problems in humans. However, the pure form of nicotine may prove to be a valuable pharmaceutical agent for the treatment of AD. However, the beneficial effects of nicotine remain a matter of much controversy. In order to clarify this issue, 12-month-old transgenic mice, expressing neuron-specific enolase (NSE)-controlled APPsw, were treated with low, middle, and high doses of nicotine for 6 months. Herein, we have concluded that the nicotine-treated groups evidenced improvements in behavior and increases in the nicotine acetylcholine receptor, nAchR alpha 7. These findings provide experimental evidence that nicotine effects an improvement in impaired memory, and that this improvement is associated with an increase in nAchR alpha 7. Thus, nicotine may prove a good preventative or therapeutic modality for AD patients.
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