Journal
NEUROCHEMICAL RESEARCH
Volume 34, Issue 1, Pages 124-137Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-008-9719-4
Keywords
Mouse genetics; Forward genetics; Mouse mutants; ENU mutagenesis; Peripheral neuropathy
Categories
Funding
- NINDS NIH HHS [R01 NS027336, R01 NS027336-18] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS027336] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Forward genetics, the phenotype-driven approach to investigating gene identity and function, has a long history in mouse genetics. Random mutations in the mouse transcend bias about gene function and provide avenues towards unique discoveries. The study of the peripheral nervous system is no exception; from historical strains such as the trembler mouse, which led to the identification of PMP22 as a human disease gene causing multiple forms of peripheral neuropathy, to the more recent identification of the claw paw and sprawling mutations, forward genetics has long been a tool for probing the physiology, pathogenesis, and genetics of the PNS. Even as spontaneous and mutagenized mice continue to enable the identification of novel genes, provide allelic series for detailed functional studies, and generate models useful for clinical research, new methods, such as the piggyBac transposon, are being developed to further harness the power of forward genetics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available