Journal
NEUROBIOLOGY OF LEARNING AND MEMORY
Volume 96, Issue 3, Pages 432-442Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2011.08.005
Keywords
Insulin; Hippocampus; Diabetes; Alzheimer's disease; Memory
Funding
- NIH [R01 DK 077106]
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Understanding of the role of insulin in the brain has gradually expanded, from initial conceptions of the brain as insulin-insensitive through identification of a role in regulation of feeding, to recent demonstration of insulin as a key component of hippocampal memory processes. Conversely, systemic insulin resistance such as that seen in type 2 diabetes is associated with a range of cognitive and neural deficits. Here we review the evidence for insulin as a cognitive and neural modulator, including potential effector mechanisms, and examine the impact that type 2 diabetes has on these mechanisms in order to identify likely bases for the cognitive impairments seen in type 2 diabetic patients. (C) 2011 Elsevier Inc. All rights reserved.
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