Journal
NEUROBIOLOGY OF LEARNING AND MEMORY
Volume 96, Issue 1, Pages 89-94Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2011.04.004
Keywords
Epigenetic; MicroRNA; Learning; Memory
Funding
- Australian Research Council [DP1096148, DP0988851]
- National Health & Medical Research Council Australia [631668]
- Australian Research Council [DP0988851, DP1096148] Funding Source: Australian Research Council
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MicroRNAs (miRNAs) are a class of endogenous, small non-coding RNAs that mediate post-transcriptional gene silencing by complementary binding to the 3'untranslated region of target mRNAs. The transient and localized expression of these small RNAs in dendrites, their capacity to respond in an activity-dependent manner, and the observation that a single miRNA can simultaneously regulate many genes, make brain-specific miRNAs ideal candidates for the fine-tuning of gene expression associated with neural plasticity and memory formation. Here we provide an overview of the current literature, which supports the proposal that non-coding RNA-mediated regulation of gene function represents an important, yet underappreciated, layer of epigenetic control that contributes to learning and memory in the adult brain. (c) 2011 Elsevier Inc. All rights reserved.
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