Journal
NEUROBIOLOGY OF LEARNING AND MEMORY
Volume 95, Issue 4, Pages 467-472Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2011.02.009
Keywords
Fragile X syndrome; Spines; Hippocampus; FMR1; FMRP
Funding
- FRAXA Research Foundation (FdeV)
- CBG
- [ZonMw 912-07-022]
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Fragile X syndrome (FXS) is the most common inherited form of mental retardation and is caused by the lack of fragile X mental retardation protein (FMRP). In the brain, spine abnormalities have been reported in both patients with FXS and Fmr1 knockout mice. This altered spine morphology has been linked to disturbed synaptic transmission related to altered signaling in the excitatory metabotropic glutamate receptor 5 (mGluR5) pathway. We investigated hippocampal protrusion morphology in adult Fmr1 knockout mice. Our results show a hippocampal CA1-specific altered protrusion phenotype, which was absent in the CA3 region of the hippocampus. This suggests a subregion-specific function of FMRP in synaptic plasticity in the brain. (C) 2011 Elsevier Inc. All rights reserved.
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