Journal
NEUROBIOLOGY OF LEARNING AND MEMORY
Volume 89, Issue 3, Pages 234-246Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2007.08.007
Keywords
protein synthesis inhibitor; gene expression; memory consolidation; memory reconsolidation
Funding
- NIDA NIH HHS [R21 DA017672-02, R21 DA017672-01, R21 DA017672, R21 CEBRA DA017672] Funding Source: Medline
- NIMH NIH HHS [R01 MH65635, R01 MH065635-04, R01 MH065635-05, R01 MH074736, R01 MH065635-06, R01 MH065635-01, R01 MH074736-01A2, R01 MH065635-02, R01 MH065635-03, R01 MH074736-02, R01 MH065635] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH074736, R01MH065635] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R21DA017672] Funding Source: NIH RePORTER
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Despite the fact that extensive evidence supports the view that phases of de novo protein synthesis are necessary for memory formation and maintenance, doubts are still raised. Skeptics generally argue that amnesia and the disruption of long-term synaptic plasticity are caused by non-specific effects of the reagents or approaches used to disrupt protein synthesis. This paper attempts to clarify some of these issues by reviewing, discussing and providing results addressing some of the major critiques that argue against the idea that de novo protein synthesis is necessary for the stabilization of long-term memory. (C) 2007 Elsevier Inc. All rights reserved.
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