Journal
NEUROBIOLOGY OF LEARNING AND MEMORY
Volume 89, Issue 1, Pages 61-69Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2007.08.016
Keywords
learning and memory; animal cognition; context; classical conditioning; fear learning; CA3; CA1; encoding and retrieval; dorsal hippocampus; ventral hippocampus
Funding
- NIMH NIH HHS [R01 MH065314-04, R01 MH065314, R01MH065314] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH065314] Funding Source: NIH RePORTER
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The present study was designed to dissociate the roles of dorsal CA3, dorsal CA1, ventral CA3, and ventral CA1 in contextual and auditory-cued classical fear conditioning. Rats received excitotoxic lesions of dorsal CA3, dorsal CA1, ventral CA3, or ventral CA3 prior to acquisition of classical fear conditioning. Dorsal CA3 and dorsal CA 1, but not ventral CA3 or ventral CA 1, lesions caused a deficit for the acquisition of contextual fear. Dorsal CA1, ventral CA3, and ventral CA1, but not dorsal CA3, lesions caused deficits for the retrieval/expression of contextual fear when tested either 24 or 48 It after encoding. Ventral CA3, but not dorsal CA3, dorsal CA1, or ventral CA1, lesions caused a deficit for retrieval of auditory-cued fear when tested either 24 or 48 It after encoding. The data suggest that dorsal CA3 mediates encoding of contextual fear, whereas ventral CA3 mediates retrieval of contextual fear. The data also suggest that dorsal CA1 mediates encoding and retrieval of contextual fear, whereas ventral CA1 mediates only the retrieval of contextual fear. (C) 2007 Elsevier Inc. All rights reserved.
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