Journal
NEUROBIOLOGY OF DISEASE
Volume 72, Issue -, Pages 84-91Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2014.03.019
Keywords
Parkinson's disease; Type 2 diabetes; Neurodegeneration; Inflammation; Insulin resistance
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Funding
- US Army Medical Research and Materiel Command [W81XWH-09-0708, W81XVVH13-1-0025]
- CurePSP - Foundation for PSP, CBD and Related Brain Diseases [507-12]
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A growing body of evidence indicates an increased risk for developing Parkinson's disease (PD) among people with type 2 diabetes (T2DM). The relationship between the etiology and development of both chronic diseases is beginning to be uncovered and recent studies show that PD and 12DM share remarkably similar dysregulated pathways. It has been proposed that a cascade of events including mitochondrial dysfunction, impaired insulin signaling, and metabolic inflammation trigger neurodegeneration in T2DM models. Network-based approaches have elucidated a potential molecular framework linking both diseases. Further, transcriptional signatures that modulate the neurodegenerative phenotype in T2DM have been identified. Here we contextualize the current experimental approaches to dissect the mechanisms underlying the association between PD and T2DM and discuss the existing challenges toward the understanding of the coexistence of these devastating aging diseases. (C) 2014 Elsevier Inc. All rights reserved.
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