Journal
NEUROBIOLOGY OF DISEASE
Volume 72, Issue -, Pages 37-47Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2014.05.033
Keywords
Alzheimer's disease; Amyloid-beta; Niemann-Pick type C disease; NPC1; Tau; Cholesterol; Lipids
Categories
Funding
- Swedish Research Council Formas
- Knut and Alice Wallenberg Foundation
- Wolfson Foundation
- Ministry of Science, Education and Sports of the Republic of Croatia
- Unity through Knowledge Fund
- Swedish State Support for Clinical Research
Ask authors/readers for more resources
Alzheimer's disease (AD) and Niemann-Pick type C (NPC) disease are progressive neurodegenerative diseases with very different epidemiology and etiology. AD is a common cause of dementia with a complex polyfactorial etiology, including both genetic and environmental risk factors, while NPC is a very rare autosomal recessive disease. However, the diseases share some disease-related molecular pathways, including abnormal cholesterol metabolism, and involvement of amyloid-beta (A beta) and tau pathology. Here we review recent studies on these pathological traits, focusing on studies of A beta and tau pathology in NPC, and the importance of the NPC1 gene in AD. Further studies of similarities and differences between AD and NPC may be useful to increase the understanding of both these devastating neurological diseases. (C) 2014 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available