Journal
NEUROBIOLOGY OF DISEASE
Volume 51, Issue -, Pages 3-12Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2011.12.057
Keywords
Alzheimer's disease; Autophagy; Bioenergetics; Biogenesis; Fission; Mitochondria; Mitochondrial DNA; Mitochondrial dysfunction; Mitochondrial medicine
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Funding
- University of Kansas School of Medicine Physician Scientist Training Program
- University of Kansas Alzheimer's Center [NIA P30 AG035982]
- Frank and Evangeline Thompson Alzheimer's Therapeutic Development Fund
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Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects a staggering percentage of the aging population and causes memory loss and cognitive decline. Mitochondrial abnormalities can be observed systemically and in brains of patients suffering from AD, and may account for part of the disease phenotype. In this review, we summarize some of the key findings that indicate mitochondrial dysfunction is present in AD-affected subjects, including cytochrome oxidase deficiency, endophenotype data, and altered mitochondria! morphology. Special attention is given to recently described perturbations in mitochondrial autophagy, fission-fusion dynamics, and biogenesis. We also briefly discuss how mitochondrial dysfunction may influence amyloidosis in Alzheimer's disease, why mitochondria are a valid therapeutic target, and strategies for addressing AD-specific mitochondrial dysfunction. (C) 2012 Elsevier Inc. All rights reserved.
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