Journal
NEUROBIOLOGY OF DISEASE
Volume 58, Issue -, Pages 179-182Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2013.05.013
Keywords
Huntington's disease; Caffeine; Adenosine receptors
Categories
Funding
- Inserm
- CNRS
- IMPRT
- University of Lille2
- Lille County Hospital (CHRU-Lille)
- Region Nord-Pas-de-Calais
- ANR
- PHC/EGIDE/PESSOA
- France Alzheimer
- LECMA
- Region Nord/Pas-de-Calais
- CHR-Lille
- reference center predictive biomarkers program in HD (Henri Mondor Hospital) (GIS-Maladies Rares appel d'offre) [A02216JS, A04159JS]
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Habitual consumption of caffeine, a non-selective adenosine receptor (AR) antagonist, has been suggested to be beneficial in Parkinson's and Alzheimer's diseases. Experimental evidence support that ARs play a role in Huntington's disease (HD) raising the hypothesis that caffeine may be a life-style modifier in HD. To determine a possible relationship between caffeine consumption and age at onset (AAO) in HD, we retrospectively assessed caffeine consumption in 80 HD patients using a dietary survey and determined relationship with AAO. Following adjustment for gender, smoking status and CAG repeat length, caffeine consumption greater than 190 mg/day was significantly associated with an earlier AAO. These data support an association between habitual caffeine intake and AAO in HD patients, but further studies are warranted to understand the link between these variables. (C) 2013 Elsevier Inc. All rights reserved.
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