Journal
NEUROBIOLOGY OF DISEASE
Volume 45, Issue 2, Pages 796-803Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2011.11.003
Keywords
Endophenotypes; Kalirin; Schizophrenia; Schizoaffective; Auditory cortex; Dendrite
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Funding
- NIH [MH071533, MH084053, MH071316, F31AG031621-01A2, 1F31MH087043]
- Doris Duke Charitable Foundation
- BMS Foundation
- Bristol-Myers Squibb
- Curridium Ltd
- Pfizer
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Reductions in dendritic arbor length and complexity are among the most consistently replicated changes in neuronal structure in post mortem studies of cerebral cortical samples from subjects with schizophrenia, however, the underlying molecular mechanisms have not been identified. This study is the first to identify an alteration in a regulatory protein which is known to promote both dendritic length and arborization in developing neurons, Kalirin-9. We found Kalirin-9 expression to be paradoxically increased in schizophrenia. We followed up this observation by overexpressing Kalirin-9 in mature primary neuronal cultures, causing reduced dendritic length and complexity. Kalirin-9 overexpression represents a potential mechanism for dendritic changes seen in schizophrenia. Published by Elsevier Inc.
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