Journal
NEUROBIOLOGY OF DISEASE
Volume 37, Issue 3, Pages 493-502Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2009.10.005
Keywords
Neuroinflammation; Gliosis; Astrocytosis; Astrocytes; Microgliosis; Microglia; Amyotrophic lateral sclerosis (ALS); Superoxide dismutase 1 (SOD1); Spinal muscular atrophy (SMA)
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Funding
- Muscular Dystrophy Association/Wings-over-Wall Street, US National Institutes of Health [NS042269, NS062180, NS064191, NS38370, NS11766, AG 21617, NS062055]
- US Department of Defense [DAMD 17-03-1, W81XWH-08-1-0522, W81XWH-08-1-0465]
- Hartman Foundation
- Parkinson's Disease Foundation
- Association Francaise contre les Myopathies (AFM)
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P01NS011766, R21NS072182, R01NS051419, P50NS011766, P50NS038370, R21NS062180, R01NS042269, R21NS064191, R01NS062055] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG021617] Funding Source: NIH RePORTER
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Indices of neuroinflammation are found in a variety of diseases of the CNS including amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Over the years, neuroinflammation, in degenerative disorders of the CNS. has evolved from being regarded as an innocent bystander accomplishing its housekeeping function secondary to neurodegeneration to being considered as a bona fide contributor to the disease process and, in some situations, as a putative initiator of the disease. Herein, we will review neuroinflammation in both ALS and SMA not only from the angle of neuropathology but also from the angle of its potential role in the pathogenesis and treatment of these two dreadful paralytic disorders. (C) 2009 Elsevier Inc. All rights reserved.
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