Journal
NEUROBIOLOGY OF DISEASE
Volume 37, Issue 2, Pages 275-283Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2009.10.003
Keywords
Stroke; Stem cells; Transplantation; Regenerative medicine; Translational studies
Categories
Funding
- NIH NINDS [R01 NS27292, P01 NS37520, R01 NS058784]
- William Randolph Hearst Foundation
- Bernard and Ronni Lacroute
- Russell and Elizabeth Siegelman
- Edward E. Hills Fund
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Stein cell transplantation has evolved as a promising experimental treatment approach for stroke. In this review. we address the major hurdles for successful translation from basic research into clinical applications and discuss possible strategies to overcome these issues. We summarize the results from present pre-clinical and clinical studies and focus on specific areas of current controversy and research: (i) the therapeutic time window for cell transplantation; (ii) the selection of patients likely to benefit from such a therapy; (iii) the optimal route of cell delivery to the ischemic brain; (iv) the most suitable cell types and sources; (v) the potential mechanisms of functional recovery after cell transplantation; and (vi) the development of imaging techniques to monitor cell therapy. (c) 2009 Elsevier Inc. All rights reserved.
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