Journal
NEUROBIOLOGY OF DISEASE
Volume 39, Issue 3, Pages 229-241Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2010.04.020
Keywords
Pathogenesis; Biochemical marker; Proteins; Early diagnosis; Neurodegenerative disorders; Proteomics
Categories
Funding
- Neuroscience Campus Amsterdam (NCA)
- VU University Medical Center Amsterdam
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The inaccuracy of the early diagnosis of Parkinson's disease (PD) has been a major incentive for studies aimed at the identification of biornarkers. Brain-derived cerebrospinal fluid (CSF) proteins are potential biomarkers considering the major role that proteins play in PD pathogenesis. In this review, we discuss the current hypotheses about the pathogenesis of PD and identify the most promising candidate biomarkers among the CSF proteins studied so far. The list of potential markers includes proteins involved in various pathogenetic processes, such as oxidative stress and protein aggregation. This list will undoubtedly grow in the near future by application of CSF proteomics and subsequent validation of identified proteins. Probably a single biomarker will not suffice to reach high sensitivity and specificity, because PD is pathogenetically heterogeneous and shares etiological factors with other neurodegenerative diseases. Furthermore, identified candidate biomarkers will have to be thoroughly validated before they can be implemented as diagnostic aids. (C) 2010 Elsevier Inc. All rights reserved.
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