Journal
NEUROBIOLOGY OF DISEASE
Volume 37, Issue 1, Pages 195-207Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2009.10.002
Keywords
Subplate neuron; Glutamate excitotoxicity; Development; Cell death
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Funding
- NIH NINDS [K02 NS047098]
- March of Dimes Research [6-FY2008]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [K02NS047098] Funding Source: NIH RePORTER
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Cerebral hypoxia-ischemia results in unique patterns of injury during development owing to selective vulnerability of specific cell populations including subplate neurons. To evaluate the contribution of glutamate excitotoxicity. we studied enriched cultures of subplate neurons in comparison with cortical neurons. deriving expression profiles for glutamate receptor subunits by microarray and immunoblot The excitotoxic potency of specific glutamate receptors was tested with selective agonists and antagonists After I week in culture. subplate neurons are more sensitive to oxygen-glucose deprivation than cortical neurons, confirming in vivo observations. Subplate and cortical neurons are equally sensitive to glutamate and insensitive to NMDA. Subplate neurons are more sensitive than cortical neurons to AMPA and express twofold less GluR2. Subplate neurons express significantly more mGluR3, a receptor proposed to be protective Despite this increased expression. group II mGluR agonists increase subplate neuron death and antagonists lessen glutamate excitotoxicity. suggesting a novel mechanism for subplate vulnerability. (C) 2009 Elsevier Inc. All rights reserved.
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