Journal
NEUROBIOLOGY OF DISEASE
Volume 38, Issue 2, Pages 148-153Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2009.09.003
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Funding
- NIMH NIH HHS [R01 MH066084, R01 MH066084-05, K02 MH074958-05, K02 MH074958] Funding Source: Medline
- NINDS NIH HHS [R21 NS055783, R21 NS055783-02] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH066084, K02MH074958] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R21NS055783] Funding Source: NIH RePORTER
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The Wnt signaling pathway is one of the central morphogenic signaling pathways regulating early vertebrate development. In recent years, it has become clear that the Wnt pathway also regulates many aspects of nervous system development from the patterning stage through the regulation of neural plasticity. In this review, we first present an overview of the components of the Wnt signaling pathway and then go on to discuss the literature describing the multitude of roles of Wnts in nervous system. In the latter portion of the review, we turn to the ways that defects in Wnt signaling lead to neurologic disease. (C) 2009 Elsevier Inc. All rights reserved.
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