Journal
NEUROBIOLOGY OF DISEASE
Volume 35, Issue 2, Pages 117-127Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2009.04.010
Keywords
Multiple sclerosis; Clinically isolated syndrome; Cerebrospinal fluid; Biomarker; Demyelination; Remyelination; Axonal damage; Glial activation; Blood-brain barrier; Blood-CSF barrier
Categories
Funding
- Multiple Sclerosis Society [835] Funding Source: Medline
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In patients with multiple sclerosis (MS) intensive efforts are directed at identifying biomarkers in bodily fluids related to underlying disease mechanisms, disease activity and progression, and therapeutic response. Besides MR imaging parameters cerebrospinal fluid (CSF) biomarkers provide important and specific information since changes in the CSF composition may reflect disease mechanisms inherent to MS. The different cellular and protein-analytical methods of the CSF and the recommended standard of the diagnostic CSF profile in MS are described. A brief update on possible CSF biomarkers that might reflect key pathological processes of MS such as inflammation, demyelination, neuroaxonal loss, gliosis and regeneration is provided. (C) 2009 Elsevier Inc. All rights reserved.
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