Journal
NEUROBIOLOGY OF DISEASE
Volume 33, Issue 3, Pages 518-525Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2008.12.014
Keywords
Alzheimer's disease; c-Jun N-terminal kinase; Amyloid-precursor protein; Oligomers; Phosphorylation; D-JNKI1; Intracellular signalling
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Funding
- FNRS (Swiss National Science Foundation) [310000-107888]
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Secretion of Amyloid-beta peptide (A beta) circulating oligomers and their aggregate forms derived by processing of beta-amyloid precursor protein (APP) are a key event in Alzheimer's disease (AD). We show that phosphorylation of APP on threonine 668 may play a role in APP metabolism in H4-APP(sw) cell line, a degenerative AD model. We proved that INK plays a fundamental role in this phosphorylation since its specific inhibition, with the INK inhibitor peptide (D-JNKI1), induced APP degradation and prevented APP phosphorylation at T668. This results in a significant drop of beta APPs, A beta fragments and A beta circulating oligomers. Moreover the D-JNKI1 treatment produced a switch in the APP metabolism, since the peptide reduced the rate of the amyloidogenic processing in favour of the non-amyloidogenic one. All together our results suggest an important link between APP metabolism and the JNK pathway and contribute to shed light on the molecular signalling pathway of this disease indicating JNK as an innovative target for AD therapy. Published by Elsevier Inc.
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