Journal
NEUROBIOLOGY OF AGING
Volume 74, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2018.09.022
Keywords
Parkinson's disease; Age at onset; DNM3
Categories
Funding
- South-Eastern Norway Regional Health Authority
- Research Council of Norway
- Norwegian Health Association
- Mayo Clinic Center for Individualized Medicine
- Mayo Clinic Neuroscience Focused Research Team (Cecilia and Dan Carmichael Family Foundation)
- Mayo Clinic Neuroscience Focused Research Team (James C. and Sarah K. Kennedy Fund for Neurodegenerative Disease Research at Mayo Clinic in Florida)
- Sol Goldman Charitable Trust
- NINDS [R01 NS078086, NS072187]
- Department of Defense award [W81XWH-16-PRMRP-IIRA]
- Michael J. Fox Foundation
- AbbVie
- Avid Radiopharmaceuticals
- Biogen
- BioLegend
- Bristol-Myers Squibb
- GE Healthcare
- Genentech
- GlaxoSmithKline
- Lilly
- Lundbeck
- Merck
- Meso Scale Discovery
- Pfizer
- Piramal
- Roche
- Sanofi Genzyme
- Servier
- Takeda
- Teva
- UCB
- Michael J. Fox Foundation for Parkinson's Research
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Parkinson's disease (PD) is a disorder with highly variable clinical phenotype. The identification of genetic variants modifying age at onset and other traits is of great interest because it may provide insight into disease mechanisms and potential therapeutic targets. A variant in the DNM3 gene (rs2421947) has been reported as a genetic modifier of age at onset in LRRK2-associated PD. To test the possible effect of genetic variation in DNM3 on age at onset in idiopathic PD, we examined rs2421947 in a total of 5918 patients with PD from seven data sets. We also assessed the potential effect of all common variants in the DNM3 locus. There was no significant association between rs2421947 and age at onset in any of the individual studies. Meta-analysis of the seven studies was nonsignificant and the between-study heterogeneity was minimal. No other common variants within the DNM3 locus affected age at onset. In conclusion, we find no evidence of an association between DNM3 variants and age at onset in idiopathic PD. (C) 2018 Elsevier Inc. All rights reserved.
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