Journal
NEUROBIOLOGY OF AGING
Volume 35, Issue 2, Pages 373-377Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2013.08.020
Keywords
Endothelial dysfunction; Tissue plasminogen activator; Von Willebrand factor; Cerebral blood flow
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Funding
- Bristol-Myers Squibb, USA
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We investigated the association of 2 markers of endothelial dysfunction, tissue plasminogen activator (t-PA) and Von Willebrand factor (VWF), with cerebral blood flow (CBF) in 541 older participants at high risk for cardiovascular disease. Serum levels of t-PA and VWF were measured at baseline. Participants underwent 2 successive brain magnetic resonance imaging scans, first at baseline and the then after a mean follow-up of 33 months. Total CBF was determined in each scan and also standardized for brain parenchymal volume. At baseline, higher t-PA was associated with lower CBF (p = 0.034). In the longitudinal analysis, higher levels of VWF were associated with a steeper decline in CBF (p = 0.043). There was no association between t-PA and decrease in CBF. These associations were independent of socio-demographic and cardiovascular factors. In conclusion, elevated markers of endothelial dysfunction are associated with lower CBF in older adults at risk for cardiovascular disease. (C) 2014 Elsevier Inc. All rights reserved.
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