Journal
NEUROBIOLOGY OF AGING
Volume 35, Issue 8, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2014.03.007
Keywords
Alzheimer's disease; Exome array; APOE; APOC1; TOMM40
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Funding
- Korea Healthcare technology R & D Project, Ministry of Health & Welfare, Republic of Korea [A092042]
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Genetic variants so far identified explain a small fraction of the overall inherited risk of Alzheimer's disease (AD). We aimed to identify novel genetic variants in AD using exome array that contains comprehensive panel. We genotyped 295,988 variants in 1005 subjects (400 AD cases and 605 controls) using Axiom Exome Genotyping Array that contains a pool of variants discovered in over 16 major human exome sequencing initiatives. Logistic regression analysis and the sequence kernel association optimal test were performed. The APOE, APOC1, and TOMM40 showed significant associations with AD in the single variant analysis. However, no significant association of other variants with AD was observed. This exome array study failed to identify novel genetic variants in AD. (C) 2014 Elsevier Inc. All rights reserved.
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