Journal
NEUROBIOLOGY OF AGING
Volume 35, Issue 6, Pages 1286-1292Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2014.01.003
Keywords
Alzheimer's disease; Neutrophils; Amyloid plaques; Immune cells
Categories
Funding
- National Research Foundation of Korea [2012R1A2A1A01002881, MRC [2011-0030738]]
- Korea National Institute of Health ROAD R&D Program Project [A092058]
- Korea Institute of Science and Technology Institutional Program [2E24242- 13e135]
- Cooperative Research Program for Agriculture Science & Technology Development [PJ009103]
- Korea Health Promotion Institute [A092058, HI09C1360010013] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2013H1A2A1033261, 2012R1A5A2A44671346] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Rural Development Administration (RDA), Republic of Korea [PJ009103032013] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Immune responses in the brain are thought to play a role in disorders of the central nervous system, but an understanding of the process underlying how immune cells get into the brain and their fate there remains unclear. In this study, we used a 2-photon microscopy to reveal that neutrophils infiltrate brain and migrate toward amyloid plaques in a mouse model of Alzheimer's disease. These findings suggest a new molecular process underlying the pathophysiology of Alzheimer's disease. (C) 2014 Elsevier Inc. All rights reserved.
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