Journal
NEUROBIOLOGY OF AGING
Volume 34, Issue 6, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2012.10.019
Keywords
Parkinson's disease; GWAS; Genetic association study; Single-nucleotide polymorphism
Categories
Funding
- The Norwegian Parkinson Association Research Fund
- Reberg's Legacy
- The Swedish Medical Research Council
- The Swedish Parkinson Foundation
- The Swedish Parkinson's Disease Association
- King GustafV's and Queen Victoria's Freemason foundation
- Swedish Brain Power
- Ahlen's foundation
- Health Region South-East, Norway
- Research Council of Norway
- Abbott
- Allergan
- Desitin
- UCB
- Lundbeck
- GlaxoSmithKline
- Medtronic
- Orion
- NordicInfu Care
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Genome-wide association studies have identified a number of susceptibility loci in sporadic Parkinson's disease (PD). Recent larger studies and meta-analyses have greatly expanded the list of proposed association signals. We performed a case-control replication study in a Scandinavian population, analyzing samples from 1345 unrelated PD patients and 1225 control subjects collected by collaborating centers in Norway and Sweden. Single-nucleotide polymorphisms representing 18 loci previously reported at genome-wide significance levels were genotyped, as well as 4 near-significant, suggestive, loci. We replicated 11 association signals at p < 0.05 (SNCA, STK39, MAPT, GPNMB, CCDC62/HIP1R, SYT11, GAK, STX1B, MCCC1/LAMP3, ACMSD, and FGF20). The more recently nominated susceptibility loci were well represented among our positive findings, including 3 which have not previously been validated in independent studies. Conversely, some of the more well-established loci failed to replicate. While future meta-analyses should corroborate disease associations further on the level of common markers, efforts to pinpoint functional variants and understand the biological implications of each risk locus in PD are also warranted. (C) 2013 Elsevier Inc. All rights reserved.
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