Journal
NEUROBIOLOGY OF AGING
Volume 34, Issue 5, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2012.10.001
Keywords
Parkinson disease; Genetics; C9ORF72; Hexanucleotide repeat
Categories
Funding
- National Institutes of Health [P30-NS069329-01, K08-NS075094, RO1NS41509, RO1NS075321, P30 NS057105, UL1 TR000448]
- American Parkinson Disease Association (APDA) Advanced Research Center for Parkinson Disease at Washington University in St. Louis
- Barnes Jewish Hospital Foundation
- Greater St. Louis Chapter of the APDA
Ask authors/readers for more resources
Hexanucleotide expansions in the C9ORF72 gene are frequently found in patients with amyotrophic lateral sclerosis, frontotemporal dementia or both, some of whom exhibit concurrent extrapyramidal symptoms. To determine if repeat expansions are a cause of Parkinson's disease (PD), we used repeat-primed polymerase chain reaction to investigate the frequency of C9ORF72 repeat expansions in a cohort of 478 patients with PD and 662 control subjects. Three control subjects were found to be expansion carriers, and no expansions were found among patients, suggesting that C9ORF72 expansions are not a common cause of PD. (C) 2013 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
