Journal
NEUROBIOLOGY OF AGING
Volume 33, Issue 1, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2010.06.015
Keywords
Mild cognitive impairment; Alzheimer's disease; Positron emission tomography; (11)C-PIB; (18)F-FDG; Cognition
Categories
Funding
- Novartis AB
- Pfizer
- GE Health Care
- Johnson Johnson
- Swedish Research Council [05817]
- (ALF) Stockholm County Council
- Karolinska Institutet
- Foundation for Old Servants
- Gun och Bertil Stohne's Foundation
- KI Foundations
- Alzheimer Foundation in Sweden
- Swedish Brain Foundation
- Swedish Brain Power
- EC-FP5 [QLK6-CT-2000-00502]
- EC-FP6 [QLK6-CT-2000-00502, LSHB-CT-2005-512146]
- Novartis Pharmaceuticals Basel
- Torreypines Therapeutics
- GSK
- Wyeth
- Bayer
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In this study 5 patients with mild cognitive impairment (MCI) and 9 Alzheimer's disease (AD) patients underwent respectively 3- and 5-year follow-up positron emission tomography (PET) studies with N-methyl [(11)C] 2-(4-methylaminophenyl)-6-hydroxy-benzothiazole ((11)C-PIB) and (18)F-fluorodeoxyglucose ((18)F-FDG) to understand the time courses in AD disease processes. Significant increase in PIB retention as well as decrease in regional cerebral metabolic rate of glucose (rCMRglc) was observed at group level in the MCI patients while no significant change was observed in cognitive function. At group level the AD patients showed unchanged high PIB retention at 5-year follow-up compared with baseline. At the individual level, increased, stable, and decreased PIB retention were observed while disease progression was reflected in significant decrease in rCMRglc and cognition. In conclusion, after a long-term follow-up with PET, we observed an increase in fibrillar amyloid load in MCI patients followed by more stable level in clinical AD patients. The rCMRglc starts to decline in MCI patients and became more pronounced in clinical stage which related to continuous decline in cognition. (C) 2012 Elsevier Inc. All rights reserved.
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