Journal
NEUROBIOLOGY OF AGING
Volume 33, Issue 8, Pages 1564-1578Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2011.06.007
Keywords
Alzheimer's disease; Mild cognitive impairment; Functional MRI (fMRI); Resting state fMRI
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Funding
- Bayer Schering Pharma
- Biogen-Dompe
- Merck Serono
- Teva Pharmaceutical Industries Ltd
- Bayer-Schering
- Teva Pharmaceutical Industries Ltd.
- Fondazione Italiana Sclerosi Multipla (FISM)
- Fondazione Mariani
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Using resting state (RS) functional magnetic resonance imaging (fMRI), the connectivity patterns of the default mode (DMN), frontoparietal, executive, and salience networks were explored in 13 Alzheimer's disease (AD) patients, 12 amnestic mild cognitive impairment (aMCI) patients, and 13 healthy controls. Compared with controls and aMCI, AD was associated with opposing connectivity effects in the DMN (decreased) and frontal networks (enhanced). The only RS abnormality found in aMCI patients compared with controls was a precuneus connectivity reduction in the DMN. RS fMRI group differences were only partly related to gray matter atrophy. In AD patients, the mean executive network connectivity was positively associated with frontal-executive and language neuropsychological scores. These results suggest that AD is associated with an alteration of large-scale functional brain networks, which extends well beyond the DMN. In AD, the limited resources of the DMN may be paralleled, in an attempt to maintain cognitive efficiency, by an increased prefrontal connectivity. A medial parietal RS fMRI signal change seems to be present since the early phase of AD. (C) 2012 Elsevier Inc. All rights reserved.
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