Journal
NEUROBIOLOGY OF AGING
Volume 33, Issue 8, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2011.12.036
Keywords
Alzheimer's disease (AD); Age-related macular degeneration (AMD); Complement pathway; Single nucleotide polymorphisms (SNPs); Genetic models
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Funding
- Alzheimer's Research UK
- MRC Centre for Neurodegeneration Research
- NIHR BRC Centre for Mental Health at the South London
- Maudsley NHS Foundation Trust
- Alzheimer's Society
- European Union [HEALTH-F4-2009-242257]
- Ulster Garden Villages, Research and Development Office, Health and Personal Social Services, Northern Ireland
- Alzheimers Research UK [ART-RF2007-3] Funding Source: researchfish
- Medical Research Council [G0902227, G0801418B, G1000718] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10084] Funding Source: researchfish
- MRC [G0902227, G1000718] Funding Source: UKRI
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Alzheimer's disease (AD) and age-related macular degeneration (AMD) are both neurodegenerative disorders which share common pathological and biochemical features of the complement pathway. The aim of this study was to investigate whether there is an association between well replicated AMD genetic risk factors and AD. A large cohort of AD (n = 3898) patients and controls were genotyped for single nucleotide polymorphisms (SNPs) in the complement factor H (CFH), the Age-related maculopathy susceptibility protein 2 (ARMS2) the complement component 2 (C2), the complement factor B (CFB), and the complement component 3 (C3) genes. While significant but modest associations were identified between the complement factor H, the age-related maculopathy susceptibility protein 2, and the complement component 3 single nucleotide polymorphisms and AD, these were different in direction or genetic model to that observed in AMD. In addition the multilocus genetic model that predicts around a half of the sibling risk for AMD does not predict risk for AD. Our study provides further support to the hypothesis that while activation of the alternative complement pathway is central to AMD pathogenesis, it is less involved in AD. (C) 2012 Elsevier Inc. All rights reserved.
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