Journal
NEUROBIOLOGY OF AGING
Volume 33, Issue 5, Pages 856-866Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2010.07.020
Keywords
Alzheimer's disease; AD; Magnetic resonance imaging; MRI; Imaging; Maternal history; Hippocampus; Atrophy; Biomarker; Hereditary; Genetic
Categories
Funding
- NIH [U01 AG024904, U54 RR021813]
- National Institute of Aging (NIA) [K23 AG026803, P50 AG16570]
- National Institute of Biomedical Imaging and Bioengineering (NIBIB) [EB01651]
- Foundation for the National Institutes of Health
- Pfizer Inc.
- Wyeth Research
- Bristol-Myers Squibb
- Eli Lilly and Company
- GlaxoSmithKline
- Merck Co. Inc.
- AstraZeneca AB
- Novartis Pharmaceuticals Corporation
- Alzheimer's Association
- Eisai Global Clinical Development
- Elan Corporation plc
- Forest Laboratories
- Institute for the Study of Aging (ISOA)
- Northern California Institute for Research and Education
- AFAR
- John A. Hartford Foundation
- Atlantic Philanthropies
- Starr Foundation
- Easton Consortium for Alzheimer Drug Discovery and Biomarker Development
- Turken Foundation
- NLM [LM05639]
- NCRR [RR019771, P41 RR013642]
- NIMH [R01 MH071940]
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We applied an automated hippocampal segmentation technique based on adaptive boosting (AdaBoost) to the 1.5 T magnetic resonance imaging (MRI) baseline and 1-year follow-up data of 243 subjects with mild cognitive impairment (MCI), 96 with Alzheimer's disease (AD), and 145 normal controls (NC) scanned as part of the Alzheimer's Disease Neuroimaging Initiative (ADNI). MCI subjects with positive maternal history of dementia had smaller hippocampal volumes at baseline and at follow-up, and greater 12-month atrophy rates than subjects with negative maternal history. Three-dimensional maps and volumetric multiple regression analyses demonstrated a significant effect of positive maternal history of dementia on hippocampal atrophy in MCI and AD after controlling for age, ApoE4 genotype, and paternal history of dementia, respectively. ApoE4 showed an independent effect on hippocampal atrophy in MCI and AD and in the pooled sample. (C) 2012 Elsevier Inc. All rights reserved.
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