Journal
NEUROBIOLOGY OF AGING
Volume 32, Issue 9, Pages 1725-1729Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2009.09.002
Keywords
Alzheimer's; AICD; APP; Fe65; Electroencephalogram; Seizure
Categories
Funding
- Alzheimer's Association
- CART-Rotary funds
- [R01AG026146]
- [5T32HD007104-31]
Ask authors/readers for more resources
Alterations in the processing of the amyloid precursor protein (APP) lead to familial Alzheimer's disease (AD). AD patients exhibit increased seizure susceptibility and alterations in their EEGs, which suggests that APP and its metabolites may modulate neuronal networks. Here we demonstrate that transgenic mice overexpressing APP intracellular domain (AICD) and its binding partner Fe65 exhibit abnormal spiking events and a susceptibility to induced seizures. These abnormalities are not observed in PDAPP (D664A) mice, which express high A beta levels but harbor a mutation in the APP intracellular domain. These data suggest that alterations in the levels of AICD contribute to network dysfunction in AD. (C) 2009 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available