Journal
NEUROBIOLOGY OF AGING
Volume 32, Issue 10, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2011.04.001
Keywords
Multiple system atrophy; Glial cytoplasmic inclusions; Alpha-synuclein; Neurodegeneration; Ataxia; Parkinsonism
Categories
Funding
- Austrian Research Foundation [FWF W1206]
- National Institute on Aging [Z01-AG000957-06]
- Austrian Science Fund (FWF) [W1206] Funding Source: Austrian Science Fund (FWF)
Ask authors/readers for more resources
Multiple system atrophy (MSA) is a fatal oligodendrogliopathy characterized by prominent alpha-synuclein inclusions resulting in a neuronal multisystem degeneration. Until recently MSA was widely conceived as a nongenetic disorder. However, during the last years a few postmortem verified Mendelian pedigrees have been reported consistent with monogenic disease in rare cases of MSA. Further, within the last 2 decades several genes have been associated with an increased risk of MSA, first and foremost the SNCA gene coding for alpha-synuclein. Moreover, genes involved in oxidative stress, mitochondrial dysfunction, inflammatory processes, as well as parkinsonism- and ataxia-related genes have been implicated as susceptibility factors. In this review, we discuss the emerging evidence in favor of genetic players in MSA. (C) 2011 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available