Journal
NEUROBIOLOGY OF AGING
Volume 32, Issue 11, Pages 2103-2105Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2009.11.016
Keywords
Down syndrome; Oxidative DNA damage; Comet assay; Coenzyme Q(10)
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Down syndrome (DS) is a chromosomal abnormality (trisomy 21) associated with a complex phenotype. Oxidative stress is known to play a major role in this pathology both due to genetic and epigenetic factors, suggesting that oxidative imbalance contributes to the clinical manifestation of DS. In particular, the implications of oxidative DNA damage in Down syndrome has been linked with neurodegeneration. Here we report the results of a double blind controlled trial aimed at investigating the protective effect of Coenzyme Q(10) on DNA oxidation in this clinical setting using the single cell gel electrophoresis technique. (C) 2009 Elsevier Inc. All rights reserved.
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